Co-stimulation is critical to the function of chimeric antigen receptor (CAR) T-cells. Previously. we demonstrated that dual co-stimulation can be effectively harnessed by a parallel (p)CAR architecture in which a CD28-containing second generation CAR is co-expressed with a 4-1BB containing chimeric co-stimulatory receptor (CCR). When compared to linear CARs. https://missouriquiltcoes.shop/product-category/binding/