Abstract Background The deregulated alternative splicing of key glycolytic enzyme. Pyruvate Kinase muscle isoenzyme (PKM) is implicated in metabolic adaptation of cancer cells. The splicing switch from normal PKM1 to cancer-specific PKM2 isoform allows the cancer cells to meet their energy and biosynthetic demands. thereby facilitating the cancer cells growth. https://www.diegojavierfares.com/hot-price-U-S-POLO-ASSN-Blue-Cotton-Men-Sweater-p18350-great-buy/