Alpers-Huttenlocher syndrome is a rare mitochondrial disease connected with mutations in the mitochondrial DNA replicase. polymerase gamma (POLG). The reduction of the activity within mitochondrial enzymes is connected with the reduction of replications level within the mitochondrial DNA. The disease manifests itself once the replications level reaches a critical point. https://www.spidertattooz.com/Antiqued-Brass-Color-Glue-On-Bar-Pin-Back-1-1-4-Inch-32mm-10-Pieces/